Science & Independent Research


Science

Sapiens Biolabs prides itself on using ingredients which have a solid body of scientific evidence on their efficiency in humans. Unlike many supplement companies, we believe in evidence before hype. We believe the key to a good supplement is knowledge of what your supplement does within the context of the body functioning: To do so, we must move beyond vague terms such as “wellness” “enhancement” and “improvement.”

While we certainly believe Sapiens Focus improves and enhances focus, well-being and cognition, we also believe that the such claims must be backed by an understanding of the underlying biomechanical processes and results. This page will touch upon the independently done, peer-reviewed science that underlies our claims. Instead of a marketing pitch that our product works, we wish to elaborate on how our product works, and how you can, independent of what we tell you, verify that it does.

The basis of our product are its ingredients, which have all been researched in multiple, independent studies. The science page will focus on the ingredients and their effects.

Finally, this is a living, evolving document. Just as science evolves, Sapiens Biolabs will continue to follow the latest research (and do our own!) to develop its products to give you the best cognitive enhancement on the market. New insights will be added, new research cited, and new ingredients, products and theories shared.

Note: Citations for basic, common and easily verifyable knowledge will be omitted. For example, the fact Rhodiola Rosea has several studies done on its efficacy in humans will be supported with a citation. The way our Alpga-GPC works as a brain nutrient will be supported with scientific citation. The fact that Rhodiola Rosea a member of the Rhodiola genera, the fact that it’s a plant or the fact acetylcholine is a neurotransmitter will not: A quick google search, a look into a botanical encyclopedia or an introductory text to human neurobiology should verify that. In other words: I will cite sources that underlie the claims we make about the product, not general knowledge that can be easily verified.


 

Rhodiola Rosea

Rhodiola rosea is a herb in the rhodiola genera (Crassulaceae family). Rhodiola Rosea has a long history of human use, mainly in fighting mental and physical fatigue. Several double-blind studies have verified it’s efficiency in doing so (Spasov, 2000), (Shevtsov, 2003). Rhodiola Rosea also has a notable effect on cognition because of this, increasing performance in associative thinking, short-term memory, calculation and speed of audiovisual perception (Darbinyan, 2000).

It’s main active compounds are Salidroside, a glucoside of tyrosol (Mao, 2007), and Rosavin (Perfumi, 2007), although Rhodiola Rosea contains several hundred minor alkaloids. An important fact to know about Rhodiola Rosea is that it works as a mild, reversible MAO-Inhibitor (Van Diemen, 2009). MAO, or Monoamine oxidase, is a family of enzymes that catalyze the oxidation of monoamines (Tipton, 2004). Monoamines are a group of endogenous chemicals, including several neurotransmitters. Inhibiting the effect of MAO is believed to be a mechanism useful increase general well-being (antidepressive effects) and mental fatigue.

This is not a problem in healthy individuals, however, if you take any psychopharmaceutical medicine, some interactions may occur. Always consult your physician before taking Rhodiola Rosea if you use psychopharmaceuticals, especially antidepressants. Combining Rhodiola Rosea with serotonin-releasing (Illegal) drugs like MDMA is not advised.

 

Caffeine

Caffeine is a central nervous system stimulant belonging to the methylxantine class (Nehlig, 1992). It is the active compound of Coffee, a beverage enjoyed for it’s effect for over five centuries. It’s use dates back to the 15th century, when it was discovered in the Sufi monasteries in Yemen (Weinberg, 2001). It is the most commonly used psychoactive drug in the world, and it has several known mechanisms of action.

It’s main mechanism of action is being an antagonist to the brain chemical adenosine, which accumulates during a prolonged wakeful state. Adenosine increases feelings of drowsiness and fatigue: When consumed, caffeine blocks the location of adenosine receptors in the synapse, making it more difficult for adenosine to exert this effect. As a result, caffeine maintains alertness. (Drugbank, 2013)

Caffeine with L-Theanine

L-Theanine is an amino acid analogue of the proteinogenic amino acids L-glutamate and L-Glutamine. It was discovered as a constituent of green tea in 1949. L-Theanine has been proven to reduce stress in healthy people. Salivary α-amylase activity (sAA) was measured as a marker of sympathetic nervous system activity. (Unno, 2013).

Several high-profile studies have been done on the combination of caffeine and l-theanine. L-Theanine with caffeine has been found to improve rapid visual information processing (RVIP) accuracy, lead to faster simple reaction time, faster numeric working memory and improved sentence verification accuracy (Haskell, 2008). Studies have also shown it increased self-reported mood and alertness (Giesbrecht, 2010). In addition, L-Theanine has been shown to reduce the increased blood pressure of caffeine, reducing the load on the body (Rodgers, 2008).

 

Alpha-GPC

Alpha-GPC or Alpha-glycerophosphocholine is a cholinergic compound that is used for its cognitive enhancement effects. It has also shown to enhance power output in athletes (Ziegenfuss, 2008). Acetylcholine is a key neurotransmitter that plays a key role in arousal, attention, memory and motivation. Acetylcholine is synthesized in the brain from choline. Alpha-GPC rapidly delivers choline to the brain across the blood-brain barrier, giving the brain the nutrients it needs to create acetylcholine. (Parnetti, 2007).

 

Panax Ginseng

Panax Ginseng is a herb that has its origin in traditional Chinese medicine(Bensky, 2004), but since has been researched by mainstream, peer-reviewed science. In one review of its effectiveness, Panax Ginseng was found to increase the health-related quality of life (Ellis, 2002). In another study, using a double-blind, placebo-controlled, balanced-crossover design, single doses of Panax Ginseng were found to lower blood glucose levels and improve cognitive performance in sustained “Mentally demanding” tasks.

The 10 minute "cognitive demand" battery comprised a Serial Threes subtraction task (2 min); a Serial Sevens subtraction task (2 min); a Rapid Visual Information Processing task (5 min); and a "mental fatigue" visual analogue scale. Blood glucose levels were measured prior to the day's treatment, and before and after the post-dose completions of the battery. (Reay, 2006).

Another study done on post-menopausal women was performed to assess the efficacy of panax ginseng on increasing health-related quality of life. While the research was found inconclusive in this population, the research showed a significant decrease of subjective well-being compared to the placebo group (Wiklund, 1999).

 

Acetyl-L-Carnitine

Acetyl-L-Carnitine or ALCAR is an acetylated form of L-Carnitine. It’s produced naturally by the body. Acetyl-L-Carnitine is often confused with L-Carnitine, which is chemically similar but does different things in the body. Acetyl-L-Carnitine does most of its work in the brain (where it also donates it’s acetyl group to synthesize acetylcholine.)

The reason ALCAR is used above L-Carnitine is because it can cross the blood-brain barrier much easier. Once there, Acetyl-L-Carnitine plays a key role in the krebs cycle in mitochondria, which is essential for the production of ATP, a substance that powers most reactions in the cell.

 

Vitamin B12

Vitamin B12 is a water-soluble vitamin that is involved in the metabolism of every cell in the human body. It’s a cofactor in DNA synthesis and fatty & amino acid metabolism (Yamada, 2013). A lack of vitamin B12 causes various types of neuropathies, and studies have shown low levels of vitamin B12 are correlated to higher risk of depression and low mood (Morris, 2003).

 

So what's stopping you? Choose Science.

 

Citations:


Citations:

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